synephrine hcl
Sarah Scott
Updated on May 18, 2026
p-Synephrine applications include weight loss/weight management, sport performance, appetite control, energy, mental focus, and cognition. Various studies indicate that p-synephrine exerts these effects through such mechanisms as binding to β3-adrenergic receptors, which regulate lipid and carbohydrate metabolism.
Why is synephrine banned?
Bitter orange contains synephrine, which is similar to ephedra — a chemical the FDA banned because it raises blood pressure and was linked to heart attacks and stroke.
What are the side effects of synephrine?
Common side effects of Neo-Synephrine include burning, stinging, pain, increased redness of the eye, tearing or blurred vision, headache, tremor, nausea, sweating, nervousness, dizziness, drowsiness, dryness in the nose, runny nose, and sneezing. The dose of Neo-Synephrine depends on the condition being treated.
Does synephrine fail drug test?
Synephrine (and octopamine) will not cause a positive result on the confirmation drug tests. However, octopamine will show up if a steroid test is conducted. The National Collegiate Athletic Association (NCAA) bans both synephrine and octopamine.
Does synephrine work for weight loss?
Bitter orange contains synephrine which acts as a stimulant on the body. While its effects can be felt, there is almost no evidence that this safely helps people lose weight.
Is yohimbine illegal?
Yohimbe sold as a dietary supplement may not work like the prescription medication that contains yohimbine. It is illegal in the United States to market an over-the-counter product containing yohimbine as a treatment for erectile dysfunction without getting approval from the U.S. Food and Drug Administration to do so.
What is P synephrine HCL?
Synephrine, or, more specifically, p-synephrine, is an alkaloid, occurring naturally in some plants and animals, and also in approved drugs products as its m-substituted analog known as neo-synephrine.
How much synephrine is safe?
The report concluded that consumption of up to 50 mg per day of p‐synephrine alone in healthy adults ‘is not likely to cause any adverse health consequences’.
Is synephrine the same as ephedrine?
Many of these contain synephrine, a sympathomimetic amine from the plant Citrus aurantium. Synephrine is structurally similar to ephedrine and has vasoconstrictor properties.
Does synephrine raise blood pressure?
Due to the similarity in chemical structure to ephedrine and the potential sympathomimetic effects of synephrine, it is hypothesized that bitter orange may increase blood pressure (BP) and heart rate (HR).
What is ephedra in?
Ephedra (Ephedra sinica), also called ma huang, is an herb that has been used in Traditional Chinese Medicine (TCM) for more than 5,000 years, primarily to treat asthma, bronchitis, and hay fever. Ephedra is also prescribed for symptoms of cold and flu, including nasal congestion, cough, fever, and chills.
Is Neosynephrine safe?
Follow the directions on the medicine label. Never use more of this medicine than directed on the label or prescribed by your doctor. Using this medicine too long can damage the lining of your nasal passages and lead to chronic nasal congestion.
Will synephrine cause false positive?
Because of the similarity in chemical structure of ephedrine and synephrine, it is hypothesized that ingestion of a bitter orange supplement may have the potential to cause false-positive results with urine amphetamine assays.
Is DMAA illegal?
DMAA (1,3-dimethylamylamine) is an amphetamine derivative that has been marketed in sports performance and weight loss products, many of which are sold as dietary supplements. DMAA is not a dietary ingredient, and DMAA-containing products marketed as dietary supplements are illegal and their marketing violates the law.
Is pre workout allowed in the military?
The drug is found in pre-workout and weight-loss supplements. It has potentially dangerous side effects. Why did the military ban it? It is illegal in supplements and therefore banned by the military.
How many calories does synephrine burn?
Well, synephrine is one of those supplements. The problem, though, is its effects are rather mild and inconsequential when taken by itself. We recall that 50 milligrams can increase the basal metabolic rate by 60 to 70 calories.
Is synephrine a thermogenic?
p‐Synephrine is a protoalkaloid widely used in dietary supplements for weight management because of its purported thermogenic effects.
Where does it go when you lose weight?
The correct answer is that fat is converted to carbon dioxide and water. You exhale the carbon dioxide and the water mixes into your circulation until it’s lost as urine or sweat. If you lose 10 pounds of fat, precisely 8.4 pounds comes out through your lungs and the remaining 1.6 pounds turns into water.